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The results reported that AngIV had a very short half life of less than 2 minutes, however, each of the N-terminal modified compounds, such as Dihexa, exhibited elongated half-lives in comparison to the parent compound

The values are expressed as the meansstandard deviation (s.d.)

In some embodiments, the otic formulation or composition comprises between about 0.01% to about 20% by weight of the carbomer